Dimeric ent-kauranoids isolated from Isodon japonica var. Glaucocalyx and their anti-inflammatory activities.
Fitoterapia
; 174: 105840, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38296167
ABSTRACT
The phytochemical investigation of the aerial parts of Isodon japonica var. glaucocalyx afforded four undescribed (glaucocalyxin O-R, 1-4) and six known ent-kauranoids (5-10). Their structures were established using NMR and MS measurements. Compounds 1 and 2 are dimeric ent-kaurane-type diterpenoids. Moreover, the plausible biogenetic pathways for compounds 1 and 2 were proposed as Michael addition between two monomers. Eight compounds were assayed for their anti-inflammatory activity by evaluating NO production in LPS-induced RAW 267.4 cells, and compounds 7, 8 and 9 exhibited relatively remarkable anti-inflammatory activities at 10 µM.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Isodon
/
Diterpenes, Kaurane
/
Diterpenes
/
Antineoplastic Agents, Phytogenic
Language:
En
Journal:
Fitoterapia
Year:
2024
Type:
Article