Discovery of sesquiterpene from Youngia japonica with antitumor effect.
Fitoterapia
; 174: 105869, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38378132
ABSTRACT
Fourteen sesquiterpenes, including one undescribed sesquiterpene lactone, were isolated from Youngia japonica, and their structures were identified by NMR, HRESIMS, ECD and calculated ECD. Cytotoxic activities of all isolates against A549, HeLa, and 4 T1 cell lines were detected by CCK8 assay. Among them, 2 showed obvious cytotoxic activity against A549 cells. Subsequently, the production of ROS, and apoptosis of A549 cells treated with 2 were evaluated. The result showed that 2 distinctly increased the ROS level, and induced the apoptosis of A549 cells. Further anticancer mechanism studies showed that 2 increased the expression of cleaved caspase 3. Taken together, our results demonstrated that 2 might become potential leading compounds for the treatment of lung cancer.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Sesquiterpenes
/
Asteraceae
/
Antineoplastic Agents
Language:
En
Journal:
Fitoterapia
Year:
2024
Type:
Article
Affiliation country:
China