Biopolymer zein nanoparticles loaded with Moringa Oleifera extract for improved wound healing activity: Development, Qbd based optimization and in vivo study.
Int J Biol Macromol
; 263(Pt 1): 130314, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38382777
ABSTRACT
Recently, nanobiomaterials have been explored for improved biological activities and value addition to the herbal extracts. Zein is a natural biopolymer with excellent pharmaceutical characteristics for topical applications. Moringa oleifera plant possesses large number of phytopharmaceuticals and its leaves are used in wound healing since ancient time. In this study, we studied first time, encapsulation of Moringa oleifera leaves aqueous extract into zein nanoparticles which are developed and optimized using quality by design approach. Moringa oleifera leaves aqueous extract was characterized by FTIR and total phenolic content determination. Moringa oleifera leaves aqueous extract loaded zein nanoparticles were systematically characterized for particle size, PDI, zeta potential, transmission electron microscopy and loading capacity. Further, a gel having optimized formulation for topical application was prepared and characterized for pH, spreadability, extrudability and storage stability. The so developed formulation were tested for wound healing activities on animals and results clearly indicated significant activity (p < 0.05) in case of Moringa oleifera leaves aqueous extract loaded zein nanoparticles formulation than control and relatively improved wound healing than Moringa oleifera leaves aqueous extract only loaded gel . This study opens up new possibilities in exploring zein nanoparticles for herbal extract based therapeutic applications.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Zein
/
Moringa oleifera
/
Nanoparticles
Language:
En
Journal:
Int J Biol Macromol
Year:
2024
Type:
Article
Affiliation country:
India