Clinically Approved Ferric Maltol: A Potent Nanozyme with Added Effect for High-Efficient Catalytic Disinfection.
ACS Appl Mater Interfaces
; 16(9): 11251-11262, 2024 Mar 06.
Article
in En
| MEDLINE
| ID: mdl-38394459
ABSTRACT
Nanozyme has been proven to be an attractive and promising candidate to alleviate the current pressing medical problems. However, the unknown clinical safety and limited function beyond the catalysis of the most reported nanozymes cannot promise an ideal therapeutic outcome in further clinical application. Herein, we find that ferric maltol (FM), a clinically approved iron supplement synthesized through a facile scalable method, exhibits excellent peroxidase-like activity than natural horseradish peroxidase-like (HRP) and commonly reported Fe-based nanozymes, and also shows high antibacterial performance for methicillin-resistant Staphylococcus aureus (MRSA) elimination (100%) and wound disinfection. In addition, with added effects inherited from contained maltol, FM can accelerate skin barrier recovery. Therefore, the exploration of FM as a safe and desired nanozyme provides a timely alternative to current antibiotic therapy against drug-resistant bacteria.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Pyrones
/
Methicillin-Resistant Staphylococcus aureus
Language:
En
Journal:
ACS Appl Mater Interfaces
Year:
2024
Type:
Article
Affiliation country:
China