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Oxidized cellulose-filled double thermo/pH-sensitive hydrogel for local chemo-photothermal therapy in breast cancer.
Zhang, Zijian; Cui, Haoran; Wang, Xin; Liu, Jie; Liu, Guangchun; Meng, Xin; Lin, Song.
Affiliation
  • Zhang Z; Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China; Systems Engineering Institute, Academy of Military Sciences, People's Liberation Army, Tianjin 300161, China.
  • Cui H; Systems Engineering Institute, Academy of Military Sciences, People's Liberation Army, Tianjin 300161, China.
  • Wang X; Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
  • Liu J; Systems Engineering Institute, Academy of Military Sciences, People's Liberation Army, Tianjin 300161, China.
  • Liu G; Jecho Biopharmaceuticals Co., Ltd, Tianjin 300467, China.
  • Meng X; Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China. Electronic address: mengxin@tust.edu.cn.
  • Lin S; Systems Engineering Institute, Academy of Military Sciences, People's Liberation Army, Tianjin 300161, China. Electronic address: lynchpku@163.com.
Carbohydr Polym ; 332: 121931, 2024 May 15.
Article in En | MEDLINE | ID: mdl-38431421
ABSTRACT
Lumpectomy plus radiation is a treatment option offering better survival than conventional mastectomy for patients with early-stage breast cancer. However, successive radioactive therapy remains tedious and unsafe with severe adverse reactions and secondary injury. Herein, a composite hydrogel with pH- and photothermal double-sensitive activity is developed via physical crosslinking. The composite hydrogel incorporated with tempo-oxidized cellulose nanofiber (TOCN), polyvinyl alcohol (PVA) and a polydopamine (PDA) coating for photothermal therapy (PTT) triggered in situ release of doxorubicin (DOX) drug was utilized to optimize postoperative strategies of malignant tumors inhibition. The incorporation of TOCN significantly affects the performance of composite hydrogels. The best-performing TOCN/PVA7 was selected for drug loading and polydopamine coating by rational design. In vitro studies have demonstrated that the composite hydrogel exhibited high NIR photothermal conversion efficiency, benign cytotoxicity to L929 cells, pH-dependent release profiles, and strong MCF-7 cell inhibitory effects. Then the TOCN/PVA7-PDA@DOX hydrogel is implanted into the tumor resection cavity for local in vivo chemo-photothermal synergistical therapy to ablate residue tumor tissues. Overall, this work suggests that such a chemo-photothermal hydrogel delivery system has great potential as a promising tool for the postsurgical management of breast cancer.
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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Cellulose, Oxidized / Hyperthermia, Induced Language: En Journal: Carbohydr Polym Year: 2024 Type: Article Affiliation country: China

Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Cellulose, Oxidized / Hyperthermia, Induced Language: En Journal: Carbohydr Polym Year: 2024 Type: Article Affiliation country: China