Phytochemical Profiling and Assessment of Antidiabetic Activity of Curcuma Angustifolia Rhizome Methanolic Extract: An In Vitro and In Silico Analysis.
Chem Biodivers
; 21(5): e202301788, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38484132
ABSTRACT
Curcuma angustifolia Roxb. is a plant with medicinal potential, traditionally used to treat different diseases. The present study aimed to determine the antidiabetic activity of C. angustifolia rhizome inâ
vitro and in silico. The methanolic extract of C. angustifolia rhizome was analyzed by FTIR and GC-MS to determine the phytochemicals present. The antidiabetic potential of the extract was evaluated by different assays in vitro. The extract inhibited both α-amylase and α-glucosidase enzymes and the glucose diffusion through the dialysis membrane in a concentration-dependent manner with IC50 values of 530.39±0.09, 293.75±0.11, and 551.74±0.3â
µg/ml respectively. The methanolic extract also improved yeast cell's ability to take up glucose across plasma membranes and the adsorption of glucose. The findings were supported by molecular docking studies. The results showed that the methanol extract of C. angustifolia rhizome has significant antidiabetic activity and thus can be also studied to isolate the potential compound with antidiabetic activities.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Plant Extracts
/
Curcuma
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Rhizome
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Methanol
/
Alpha-Amylases
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Alpha-Glucosidases
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Molecular Docking Simulation
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Hypoglycemic Agents
Language:
En
Journal:
Chem Biodivers
Year:
2024
Type:
Article
Affiliation country:
India