The Effects of L-Carnitine Supplementation on Weight Loss, Glycemic Control, and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: A Systematic Review and Dose-response Meta-Analysis of Randomized Controlled Trials.
Clin Ther
; 46(5): 404-410, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38594107
ABSTRACT
PURPOSE:
L-carnitine supplementation has been recommended to improve cardiometabolic health markers in diabetic patients. Our purpose was to assess the dose-dependent effects of l-carnitine supplementation on cardiometabolic risk factors in patients with type 2 diabetes.METHODS:
PubMed/Medline, Scopus, and Web of Science were searched until May 2022 for randomized controlled trials that examined the impact of l-carnitine supplementation on cardiometabolic risk factors in adults with type 2 diabetes. The mean difference (MD) and its 95% confidence interval (CI) were estimated utilizing a random-effects model. Nonlinear dose-response associations were modeled with restricted cubic splines. The certainty of evidence was rated using the GRADE approach.FINDINGS:
Twenty-one randomized trials with 2041 patients with type 2 diabetes were included. We found that every 1 g/d supplementation with l-carnitine significantly reduced body mass index (MD -0.37 kg/m2, 95% CI -0.59, -0.15; I2 =93%, n=13, GRADE=low), HbA1c (MD -0.16%, 95% CI -0.32, -0.01; I2 = 94%, n = 18, GRADE = moderate), and low-density lipoprotein cholesterol (MD -0.11 mmol/L, 95% CI -0.16, -0.05; I2 = 91%, n = 11, GRADE = high). There were also reductions in serum triglycerides (MD 0.07 mmol/L), total cholesterol (MD -0.13 mmol/L), and fasting plasma glucose (MD -0.17 mmol/L). A U-shaped effect was demonstrated for body mass index, with the largest reduction at 2 g/d. A linear reduction was seen for serum triglycerides, total cholesterol, and fasting plasma glucose up to l-carnitine supplementation of 4 g/d. IMPLICATIONS L-carnitine supplementation resulted in a small reduction in serum lipids and plasma glucose in patients with type 2 diabetes. However, due to high statistical heterogeneity, the results should be interpreted very cautiously.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Blood Glucose
/
Carnitine
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Weight Loss
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Dietary Supplements
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Diabetes Mellitus, Type 2
/
Glycemic Control
Language:
En
Journal:
Clin Ther
Year:
2024
Type:
Article
Affiliation country:
Iran