Triglycerides: A Sensitizer but Not a Trigger for Hypertriglyceridemic Acute Pancreatitis.
Dig Dis Sci
; 69(6): 2123-2131, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38609542
ABSTRACT
BACKGROUND:
The incidence of hypertriglyceridemic acute pancreatitis (HTG-AP) is increasing. Although the guideline defines the diagnostic criteria as triglyceride (TG) greater than 11.3 mmol/L, there is actually no specific threshold. Many people with hypertriglyceridemia (HTG) or obvious chyloid blood do not develop acute pancreatitis (AP).AIMS:
To explore the role of HTG in the pathogenesis of AP.METHODS:
Thirty-six male SD rats were randomly assigned into normal control, AP, HTG, HTG-AP, low-dose fenofibrate and high-dose fenofibrate groups. Serum indices and cytokine levels in serum, and pathological changes in pancreatic tissues were observed. The expression levels of TLR4 and NF-κBp65 in pancreatic tissues were detected by immunohistochemistry and Western blot.RESULTS:
In normal rats, HTG alone did not induce AP. However, after establishing the HTG-AP model with Poloxam 407 and L-arginine, serum-free fatty acid and TG levels were positively correlated with the levels of lipase, amylase, IL-1ß, IL-6, pancreatic inflammation scores, and the expressions of TLR4 and NF-κBp65 (all P < 0.001). Expressions of TLR4 and NF-κBp65 were significantly increased in the pancreatic tissues of HTG-AP rats. Fenofibrate effectively decreased TG levels in HTG-AP rats and reduced the expression of TLR4 and NF-κBp65 (all P < 0.001).CONCLUSIONS:
HTG does not directly cause AP, but rather increases the susceptibility to AP or aggravates the inflammatory response. It is more like a sensitizer of inflammation rather than an activator.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Pancreatitis
/
Triglycerides
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Hypertriglyceridemia
/
Rats, Sprague-Dawley
/
Toll-Like Receptor 4
Language:
En
Journal:
Dig Dis Sci
/
Dig. dis. sci
/
Digestive diseases and sciences
Year:
2024
Type:
Article