[Effect of butadione on the morphohistochemical changes in the joints in adjuvant polyarthritis]. / Vliianie butadiona na morfogistokhimicheskie izmeneniia v sustavakh pri ad''iuvantnom polartrite.

ABSTRACT

Prophylactic and therapeutic administration of pyrasol derivatives butadion and stampyrine (antipyrilamide of stearic acid), to rats with adjuvant polyarthritis normalize the structure of the synovial membrane, capsule and of the periarticular tissue of the talocrural articulations, stabilize the proteinic-mucopolysaccharide complexes, lower the permeability of the lysosome membranes and vascular walls and inhibit the phagocystic activity of the histiocytes. Both drugs do not lessen the proliferation of the fibroblasts, but normalize the processes of the collagenogenesis them. The prophylactic and therapeutic effects of stampyrine are superior to those of butadion.