Comparative lethality of coca and cocaine.
Pharmacol Biochem Behav
; 17(5): 1087-8, 1982 Nov.
Article
in En
| MEDLINE
| ID: mdl-7178201
ABSTRACT
The 24 hour lethal effects of cocaine were compared to those of a crude ethanol extract of the coca leaf (Erthroxylon coca) in male, Swiss mice. Various doses of cocaine HCl and coca leaf extracts suspended in a Tween 60, Arlacel 83, and distilled water vehicle were injected IP into groups of 10 mice. The LD50 for cocaine was 95.1 mg/kg. The LD50 for the coca extract was 3450 mg/kg. The LD50 of the extract based on its cocaine content was 31.4 mg/kg. The results clearly indicate that the coca leaf contains constituents other than cocaine that can contribute to a toxic effect of the plant.
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Database:
MEDLINE
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
Main subject:
Plants, Medicinal
/
Coca
/
Cocaine
Language:
En
Journal:
Pharmacol Biochem Behav
Year:
1982
Type:
Article