Involvement of the brain type of ryanodine receptor in T-cell proliferation.
FEBS Lett
; 352(2): 206-10, 1994 Sep 26.
Article
in En
| MEDLINE
| ID: mdl-7523185
ABSTRACT
Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.
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Database:
MEDLINE
Main subject:
T-Lymphocytes
/
Calcium Channels
/
Muscle Proteins
Language:
En
Journal:
FEBS Lett
Year:
1994
Type:
Article
Affiliation country:
Japan