Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease.

Fink, D M; Bores, G M; Effland, R C; Huger, F P; Kurys, B E; Rush, D K; Selk, D E

Fink, D M; Bores, G M; Effland, R C; Huger, F P; Kurys, B E; Rush, D K; Selk, D E.

Affiliation

Fink DM; Department of Medicinal Chemistry, Hoechst-Roussel Pharmaceuticals, Inc, Somerville, New Jersey 08876, USA.

J Med Chem ; 38(18): 3645-51, 1995 Sep 01.

Article in En | MEDLINE | ID: mdl-7658452

Subject(s)

Alzheimer Disease/drug therapy; Aminoquinolines/pharmacology; Cholinesterase Inhibitors/pharmacology; Acetylcholinesterase/drug effects; Alkaloids; Aminoquinolines/chemistry; Animals; Cholinesterase Inhibitors/chemistry; Dementia/chemically induced; Dementia/drug therapy; Drug Evaluation; Male; Mice; Rats; Scopolamine/pharmacology; Sesquiterpenes/chemistry; Structure-Activity Relationship

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Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia Main subject: Cholinesterase Inhibitors / Alzheimer Disease / Aminoquinolines Language: En Journal: J Med Chem Year: 1995 Type: Article Affiliation country: United States

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