Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs.

Thormar, H; Georgsson, G; Pálsson, P A; Balzarini, J; Naesens, L; Torsteinsdóttir, S; De Clercq, E

Thormar, H; Georgsson, G; Pálsson, P A; Balzarini, J; Naesens, L; Torsteinsdóttir, S; De Clercq, E.

Affiliation

Thormar H; Institute of Biology, University of Iceland, Reykjavík.

Proc Natl Acad Sci U S A ; 92(8): 3283-7, 1995 Apr 11.

Article in En | MEDLINE | ID: mdl-7724553

Subject(s)

Adenine/analogs & derivatives; Antiviral Agents/therapeutic use; Disease Models, Animal; Drug Evaluation, Preclinical/methods; HIV Infections/drug therapy; Organophosphonates; Visna/drug therapy; Adenine/pharmacokinetics; Adenine/therapeutic use; Animals; Antibodies, Viral/blood; Brain/pathology; Brain/virology; Cytopathogenic Effect, Viral; Leukocytes, Mononuclear/virology; Sheep; Visna/blood; Visna/cerebrospinal fluid; Visna/immunology; Visna/virology; Visna-maedi virus/immunology; Visna-maedi virus/isolation & purification

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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Adenine / HIV Infections / Visna / Disease Models, Animal / Drug Evaluation, Preclinical / Organophosphonates Language: En Journal: Proc Natl Acad Sci U S A Year: 1995 Type: Article

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