Effects of a Dan Shen component, magnesium lithospermate B, in nephrectomized rats.
Nihon Jinzo Gakkai Shi
; 37(2): 105-11, 1995 Feb.
Article
in En
| MEDLINE
| ID: mdl-7752501
ABSTRACT
Magnesium lithospermate B, a compound newly isolated from Dan Shen, was given orally to rats for 70 days after excision of five-sixths of their kidney volume. As a result, mesangial proliferation, tubulo-interstitial lesions and glomerular sclerotic lesions, which were conspicuous in rats that were not given magnesium lithospermate B after nephrectomy, were inhibited. Furthermore, a decrease in blood urea nitrogen, improvement of hypoproteinemia, hypoalbuminemia and hypercholesteremia, and inhibition of urinary protein excretion were observed. The levels of creatinine, methylguanidine and guanidino-succinic acid, which accumulate in the blood with the progress of renal failure, were decreased significantly in rats given magnesium lithospermate B. These results indicate that magnesium lithospermate B, a component of an Oriental medicine has potential as a new therapeutic agent for inhibiting the progression of renal dysfunction.
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Database:
MEDLINE
Traditional Medicines:
Medicinas_tradicionales_de_asia
/
Medicina_china
Main subject:
Drugs, Chinese Herbal
/
Kidney Glomerulus
/
Nephrectomy
Type of study:
Etiology_studies
Language:
En
Journal:
Nihon Jinzo Gakkai Shi
Year:
1995
Type:
Article
Affiliation country:
Japan