Oxidative coupling of mithramycin and hydroquinone catalyzed by copper oxidases and benzoquinone. Implications for the mechanism of action of aureolic acid antibiotics.

Anyanwutaku, I O; Petroski, R J; Rosazza, J P

Anyanwutaku, I O; Petroski, R J; Rosazza, J P.

Affiliation

Anyanwutaku IO; Division of Medicinal and Natural Products Chemistry, University of Iowa, College of Pharmacy, Iowa City 52242.

Bioorg Med Chem ; 2(6): 543-51, 1994 Jun.

Article in En | MEDLINE | ID: mdl-8000877

Subject(s)

Antibiotics, Antineoplastic/chemical synthesis; Benzoquinones/chemistry; Ceruloplasmin/metabolism; Hydroquinones/chemistry; Oxidoreductases/metabolism; Plicamycin/analogs & derivatives; Plicamycin/chemistry; Polyporaceae/enzymology; Animals; Antibiotics, Antineoplastic/chemistry; Antibiotics, Antineoplastic/therapeutic use; Catalysis; Drug Evaluation, Preclinical; Humans; Laccase; Leukemia P388/drug therapy; Male; Mice; Mice, Inbred Strains; Molecular Structure; Plicamycin/therapeutic use; Spectrometry, Mass, Fast Atom Bombardment

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Database: MEDLINE Main subject: Oxidoreductases / Polyporaceae / Ceruloplasmin / Benzoquinones / Plicamycin / Hydroquinones / Antibiotics, Antineoplastic Type of study: Prognostic_studies Language: En Journal: Bioorg Med Chem Year: 1994 Type: Article

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