Androgen Antagonists/therapeutic use; Anilides/therapeutic use; Antineoplastic Agents/therapeutic use; Prostatic Neoplasms/drug therapy; Androgen Antagonists/metabolism; Androgen Antagonists/pharmacology; Anilides/metabolism; Anilides/pharmacology; Anilides/toxicity; Animals; Antineoplastic Agents/metabolism; Antineoplastic Agents/pharmacology; Binding, Competitive; Blood-Brain Barrier; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Humans; Macaca nemestrina; Male; Nitriles; Orchiectomy; Prostatic Neoplasms/surgery; Rats; Receptors, Androgen/drug effects; Receptors, Androgen/metabolism; Tosyl Compounds; Tumor Cells, Cultured