Synthesis and antiviral activities of 9-cyclopentylpurine derivatives.

Kojima, E; Ohta, K; Miyawaki, S; Date, T; Machida, M; Murakami, K

Kojima, E; Ohta, K; Miyawaki, S; Date, T; Machida, M; Murakami, K.

Affiliation

Kojima E; Biochemistry Section, Iwakuni Research Laboratory of Technology, Nippon Paper Industries Co. Ltd, Yamaguchi, Japan.

Nucleic Acids Symp Ser ; (34): 107-8, 1995.

Article in En | MEDLINE | ID: mdl-8841575

ABSTRACT

The synthesis and anti-RSV (Rouse Sarcoma Virus) activity of HMCA, (+/-)-9-(2-hydroxymethyl-cyclopenthyl)-adenine, and its derivatives are described. It has been demonstrated that trans-HMCA has greater anti-RSV activity in tissue culture than cis-HMCA.

Subject(s)

Adenine/analogs & derivatives; Adenine/pharmacology; Antiviral Agents/chemical synthesis; Antiviral Agents/pharmacology; Adenine/chemical synthesis; Animals; Antiviral Agents/chemistry; Avian Sarcoma Viruses/drug effects; Chick Embryo; Drug Evaluation, Preclinical; Fibroblasts; HIV-1/drug effects; In Vitro Techniques; Stereoisomerism; Structure-Activity Relationship

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Database: MEDLINE Main subject: Antiviral Agents / Adenine Language: En Journal: Nucleic Acids Symp Ser Year: 1995 Type: Article Affiliation country: Japan

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Database: MEDLINE Main subject: Antiviral Agents / Adenine Language: En Journal: Nucleic Acids Symp Ser Year: 1995 Type: Article Affiliation country: Japan