Syntheses and biological activities of dihydro-5,6-dehydrokawain derivatives.
Biosci Biotechnol Biochem
; 60(10): 1643-5, 1996 Oct.
Article
in En
| MEDLINE
| ID: mdl-8987662
ABSTRACT
The syntheses and biological activities of dihydro-5,6-dehydrokawain derivatives against plant pathogenic fungi and termites were investigated. Dihydro-5,6-dehydrokawain was isolated by a simple method without chromatography from the leaves of Alpinia speciosa K. SCHUM. The white crystalline compound obtained was identified as dihydro-5,6-dehydrokawain (1) by instrumental analyses. 4-Hydroxy-6-(2-phenylethyl)-2H-pyran-2-one (3) was prepared by hydrolyzing dihydro-5,6-dehydrokawain. Three dihydro-5,6-dehydrokawain derivatives were synthesized by reacting 3 with phosphoric agents. Among the synthesized compounds, dimethyl [6-(2-phenylethyl)-2-oxo-2H-pyran-4-yl]phosphorothionate (4) had the strongest antifungal activity of 91% at 100 ppm against Corticium rolfsii.
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Database:
MEDLINE
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
Main subject:
Plants, Medicinal
/
Pyrones
/
Insecticides
/
Antifungal Agents
Language:
En
Journal:
Biosci Biotechnol Biochem
Year:
1996
Type:
Article
Affiliation country:
Japan