The use of human hepatocytes to select compounds based on their expected hepatic extraction ratios in humans.

Lavé, T; Dupin, S; Schmitt, C; Valles, B; Ubeaud, G; Chou, R C; Jaeck, D; Coassolo, P

Lavé, T; Dupin, S; Schmitt, C; Valles, B; Ubeaud, G; Chou, R C; Jaeck, D; Coassolo, P.

Affiliation

Lavé T; F. Hoffmann-LaRoche Ltd., Basel, Switzerland.

Pharm Res ; 14(2): 152-5, 1997 Feb.

Article in En | MEDLINE | ID: mdl-9090701

Subject(s)

Liver/metabolism; Pharmacokinetics; Adult; Aged; Biological Availability; Cells, Cultured; Drug Evaluation, Preclinical/methods; Humans; Liver/cytology; Liver/enzymology; Metabolic Clearance Rate; Middle Aged; Pharmaceutical Preparations/classification; Pharmaceutical Preparations/metabolism

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Database: MEDLINE Main subject: Pharmacokinetics / Liver Language: En Journal: Pharm Res Year: 1997 Type: Article Affiliation country: Switzerland

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PubMed Links

Database: MEDLINE Main subject: Pharmacokinetics / Liver Language: En Journal: Pharm Res Year: 1997 Type: Article Affiliation country: Switzerland