Novel cephalosporin derivatives possessing a bicyclic heterocycle at the 3-position. Part I: Synthesis and biological activities of 3-(benzothiazol-2-yl)thiocephalosporin derivatives, CP0467 and related compounds.

Tsushima, M; Iwamatsu, K; Tamura, A; Shibahara, S

Tsushima, M; Iwamatsu, K; Tamura, A; Shibahara, S.

Affiliation

Tsushima M; Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.

Bioorg Med Chem ; 6(7): 1009-17, 1998 Jul.

Article in En | MEDLINE | ID: mdl-9730237

Subject(s)

Acetamides/chemical synthesis; Bacterial Proteins; Cephalosporins/chemical synthesis; Hexosyltransferases; Peptidyl Transferases; Thiazoles/chemical synthesis; Animals; Carrier Proteins/metabolism; Cephalosporins/metabolism; Cephalosporins/pharmacokinetics; Cephalosporins/pharmacology; Colony Count, Microbial; Drug Evaluation, Preclinical; Gram-Positive Bacteria/drug effects; Gram-Positive Bacteria/isolation & purification; Male; Methicillin Resistance; Mice; Muramoylpentapeptide Carboxypeptidase/metabolism; Penicillin-Binding Proteins; Penicillins/metabolism; Staphylococcus aureus/drug effects; Staphylococcus aureus/metabolism; Structure-Activity Relationship

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Database: MEDLINE Main subject: Thiazoles / Bacterial Proteins / Cephalosporins / Peptidyl Transferases / Hexosyltransferases / Acetamides Language: En Journal: Bioorg Med Chem Year: 1998 Type: Article Affiliation country: Japan

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