Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide.

Bruneau, J M; Yea, C M; Spinella-Jaegle, S; Fudali, C; Woodward, K; Robson, P A; Sautès, C; Westwood, R; Kuo, E A; Williamson, R A; Ruuth, E

Bruneau, J M; Yea, C M; Spinella-Jaegle, S; Fudali, C; Woodward, K; Robson, P A; Sautès, C; Westwood, R; Kuo, E A; Williamson, R A; Ruuth, E.

Affiliation

Bruneau JM; Immunology Domain, Hoechst Roussel, 93235 Romainville, France.

Biochem J ; 336 ( Pt 2): 299-303, 1998 Dec 01.

Article in En | MEDLINE | ID: mdl-9820804

Subject(s)

Aniline Compounds/pharmacology; Hydroxybutyrates/pharmacology; Oxidoreductases Acting on CH-CH Group Donors; Oxidoreductases/antagonists & inhibitors; Oxidoreductases/isolation & purification; Aniline Compounds/metabolism; Binding Sites; Binding, Competitive; Cell Division/drug effects; Cell Membrane/drug effects; Cell Membrane/enzymology; Crotonates; Dihydroorotate Dehydrogenase; Humans; Hydroxybutyrates/metabolism; Lymphoma/enzymology; Nitriles; Oxidoreductases/metabolism; Spleen/enzymology; Toluidines; Tumor Cells, Cultured; Uridine/metabolism; Uridine/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Oxidoreductases / Oxidoreductases Acting on CH-CH Group Donors / Hydroxybutyrates / Aniline Compounds Language: En Journal: Biochem J Year: 1998 Type: Article Affiliation country: France

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