Study of the correlation between the colorectal cancer Chinese medicine syndrome types and (excision repair cross-complementing 1, ERCC1) gene polymorphisms / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 628-632, 2012.
Article
in Zh
| WPRIM
| ID: wpr-252546
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation between excision repair cross-complementing 1 (ERCC1) C8092A and C19007T gene polymorphisms and different Chinese medicine (CM) syndrome types of colorectal cancer (CC).</p><p><b>METHODS</b>Ninety-nine patients with CC were syndrome typed as dampness-heat accumulation syndrome, qi stagnation with blood stasis syndrome, Pi-Shen yang deficiency syndrome, and Gan-Shen yin deficiency syndrome. The gene polymorphisms of excision repair cross-complementing 1 (ERCC1) C8092A and C19007T in different CM syndrome types of CC were examined by polymorphisms chain reaction amplification and direct sequencing, and analyzed statistically.</p><p><b>RESULTS</b>The frequencies of C8092A genotype and allele in different CM syndrome types had no statistical difference (P > 0.05). The frequencies of C19007T genotype and allele in different CM syndrome types had statistical difference (P < 0.05). Of them, there was no statistical difference in the frequencies between dampness-heat accumulation syndrome and qi stagnation with blood stasis syndrome, or between Pi-Shen yang deficiency syndrome and Gan-Shen yin deficiency syndrome (P > 0.05). There was statistical difference between dampness-heat accumulation syndrome and Pi-Shen yang deficiency syndrome as well as Gan-Shen yin deficiency syndrome (P < 0.05). There was statistical difference between qi stagnation with blood stasis syndrome and Pi-Shen yang deficiency syndrome as well as Gan-Shen yin deficiency syndrome (P < 0.05).</p><p><b>CONCLUSION</b>ERCC1 C19007T gene polymorphisms might be associated with CM syndrome types of CC, which needed to be further studied.</p>
Full text:
1
Database:
WPRIM
Traditional Medicines:
Medicinas_tradicionales_de_asia
/
Medicina_china
Main subject:
Polymorphism, Genetic
/
Colorectal Neoplasms
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Yin Deficiency
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Yang Deficiency
/
Diagnosis
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DNA-Binding Proteins
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Endonucleases
/
Genetics
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Genotype
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Medicine, Chinese Traditional
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2012
Type:
Article