Structured lipid emulsion as nutritional therapy for the elderly patients with severe sepsis / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 2329-2332, 2013.
Article
in En
| WPRIM
| ID: wpr-322203
Responsible library:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>The nutritional support is one of the important therapeutic strategies for the elderly patients with severe sepsis, but there is controversial in choosing a parenteral nutrition formulation. This study was designed to compare the therapeutic effects of structured lipid emulsion, physically mixed medium, and long-chain fat emulsion in the treatment of severe sepsis in elderly patients.</p><p><b>METHODS</b>A total number of 64 elder patients with severe sepsis were enrolled in the study. After a week of enteral nutritional support, the patients were randomly divided into research (structured lipid emulsion as parenteral alimentation) and control groups (physically mixed medium and long-chain fat emulsion as parenteral alimentation). The alterations of plasma albumin, lipid metabolism, and blood glucose level were recorded after parenteral alimentation and were compared between the two groups.</p><p><b>RESULTS</b>The plasma levels of albumin, prealbumin, cholesterol, and triglyceride were decreased in all the patients after one week of enteral nutritional support treatment (t = 7.78, P = 0.000; t = 10.21, P = 0.000; t = 7.99, P = 0.000; and t = 10.99, P = 0.000). Further parenteral alimentation with different lipid emulsions had significant effects on the serum prealbumin and albumin (t = 3.316, P = 0.002; t = 3.200, P = 0.002), whilst had no effects on the blood glucose and triglyceride level (t = 7.78, P = 0.000; t = 4.228, P = 0.000). In addition, the two groups had a significantly different Apache II score, ventilator time, and hospital stay time (t = -2.213, P = 0.031; t = 2.317, P = 0.024; t = 2.514, P = 0.015).</p><p><b>CONCLUSIONS</b>The structured lipid emulsion was safe as parenteral nutrition for elderly patients with severe sepsis. It was demonstrated to be superior to the physically mixed medium and long-chain fat emulsion with respect to the protein synthesis and prognosis.</p>
Full text:
1
Database:
WPRIM
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
/
Trofoterapia
Main subject:
Triglycerides
/
Blood
/
Serum Albumin
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Parenteral Nutrition
/
Sepsis
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Therapeutic Uses
/
Drug Therapy
/
Emulsions
/
Fat Emulsions, Intravenous
/
Methods
Type of study:
Prognostic_studies
Language:
En
Journal:
Chinese Medical Journal
Year:
2013
Type:
Article