Application of active components from traditional Chinese medicine in treatment of inflammatory bowel disease / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 415-421, 2019.
Article
in Zh
| WPRIM
| ID: wpr-777485
Responsible library:
WPRO
ABSTRACT
Inflammatory bowel disease(IBD) is a non-specific and chronic recurrent autoimmune disease that involves the gastrointestinal tract. Clinical symptoms of intestinal bleeding, diarrhea, and weight loss threat to human health and induce colorectal cancer. The pathogenesis included living environment, genetic factors, immune cell infiltration and immune stress, weakened mucosal barrier defense and intestinal flora imbalance. At present, clinical treatment drugs mainly include aminosalicylic acid, corticosteroids, immunosuppressants, biological agents, etc., in view of the disadvantages of poor therapeutic effect and expensive price. The active ingredients of traditional Chinese medicine(TCM) in the treatment IBD have various biological activities and multiple targets such as anti-inflammatory, antibacterial, anti-tumor and immune regulation. This article summarized the application and the research progress in protecting intestinal epithelial barrier, maintaining intestinal microbial homeostasis, inhibiting causative factors, and regulating Th1/Th17/Treg balance about TCM in the treatment of IBD. The review provided new ideas for further development of the new drugs on the mechanism based on active ingredients of TCM in IBD treatment.
Key words
Full text:
1
Database:
WPRIM
Traditional Medicines:
Medicinas_tradicionales_de_asia
/
Medicina_china
Main subject:
Therapeutics
/
Inflammatory Bowel Diseases
/
Intestinal Mucosa
/
Medicine, Chinese Traditional
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2019
Type:
Article