Bofutsushosan ameliorates obesity in mice through modulating PGC-1α expression in brown adipose tissues and inhibiting inflammation in white adipose tissues / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 449-456, 2016.
Article
in En
| WPRIM
| ID: wpr-812611
Responsible library:
WPRO
ABSTRACT
The inducible co-activator PGC-1α plays a crucial role in adaptive thermogenesis and increases energy expenditure in brown adipose tissue (BAT). Meanwhile, chronic inflammation caused by infiltrated-macrophage in the white adipose tissue (WAT) is a target for the treatment of obesity. Bofutsushosan (BF), a traditional Chinese medicine composed of 17 crude drugs, has been widely used to treat obesity in China, Japan, and other Asia countries. However, the mechanism underlying anti-obesity remains to be elucidated. In the present study, we demonstrated that BF oral administration reduced the body weight of obese mice induced by high-fat diet (HFD) and alleviated the level of biochemical markers (P < 0.05), including blood glucose (Glu), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and insulin. Our further results also indicated that oral BF administration increased the expression of PGC-1α and UCP1 in BAT. Moreover, BF also reduced the expression of inflammatory cytokines in WAT, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). These findings suggested that the mechanism of BF against obesity was at least partially through increasing gene expression of PGC-1α and UCP1 for energy consumption in BAT and inhibiting inflammation in WAT.
Key words
Full text:
1
Database:
WPRIM
Traditional Medicines:
Medicinas_tradicionales_de_asia
/
Medicina_china
Main subject:
Adipose Tissue, Brown
/
Drugs, Chinese Herbal
/
Cytokines
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Drug Therapy
/
Energy Metabolism
/
Allergy and Immunology
/
Adipose Tissue, White
/
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2016
Type:
Article