Phytochemical and biological research of Fritillaria medicine resources / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 330-344, 2013.
Article
in En
| WPRIM
| ID: wpr-812671
Responsible library:
WPRO
ABSTRACT
The genus Fritillaria is a botanical source for various pharmaceutically active components, which have been commonly used in traditional Chinese medicine for thousands of years. Increasing interest in Fritillaria medicinal resources has led to additional discoveries of steroidal alkaloids, saponins, terpenoids, glycosides and many other compounds in various Fritillaria species, and to investigations on their chemotaxonomy, molecular phylogeny and pharmacology. In continuation of studies on Fritillaria pharmacophylogeny, the phytochemistry, chemotaxonomy, molecular biology and phylogeny of Fritillaria and their relevance to drug efficacy is reviewed. Literature searching is used to characterize the global scientific effort in the flexible technologies being applied. The interrelationship within Chinese Bei Mu species and between Chinese species, and species distributed outside of China, is clarified by the molecular phylogenetic inferences based on nuclear and chloroplast DNA sequences. The incongruence between chemotaxonomy and molecular phylogeny is revealed and discussed. It is essential to study more species for both the sustainable utilization of Fritillaria medicinal resources and for finding novel compounds with potential clinical utility. Systems biology and omics technologies will play an increasingly important role in future pharmaceutical research involving the bioactive compounds of Fritillaria.
Key words
Full text:
1
Database:
WPRIM
Traditional Medicines:
Medicinas_tradicionales_de_asia
/
Medicina_china
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
Main subject:
Pharmacology
/
Phylogeny
/
Plants, Medicinal
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Chemistry
/
China
/
Classification
/
Fritillaria
Country/Region as subject:
Asia
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2013
Type:
Article