Effect of Chinese herb Suifukang on expression of NoGo-A protein in the brain of MACO rat / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 35-38, 2013.
Article
in Zh
| WPRIM
| ID: wpr-860513
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: To study the effect of Chinese herb Suifukang on the expression of Nogo protein-A in the brain of MCAO rats and explore the action mechanism of its promoting neurogenesis. METHODS: SD rats were selected and randomized into six groups: normal group, control group, treatment group of methylprednisolone, treatment group of Chinese herb Suifukang in large-does, middle-does and small-does. The models of MCAO rats were successfully established by the method of Koizumi. After the surgery, the rats of drug group had been taken orally Suifukang by 10 g · kg-1 crude drug one time daily, and the rest groups had been taken orally equivalence saline once a day. The brain of rats were investigated and the expression of NoGo-A was detected by immunohistology method and RT-PCR method. RESULTS: The expression of NoGo-A in the injured brain was apparently inhibited by Suifukang (P < 0.01). CONCLUSION: Suifukang can inhibit the expression of NoGo-A. So this function may be one of the mechanisms that Suifukang can promote the functional recovery after brain injury. Copyright 2013 by the Chinese Pharmaceutical Association.
Full text:
1
Database:
WPRIM
Type of study:
Clinical_trials
Language:
Zh
Journal:
Chinese Pharmaceutical Journal
Year:
2013
Type:
Article