The prospects of DNA damage repair variants guiding platinum compounds in the treatment of triple negative breast cancer / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 68-72, 2022.
Article
in Zh
| WPRIM
| ID: wpr-935183
Responsible library:
WPRO
ABSTRACT
Triple negative breast cancer (TNBC) is prone to recurrence and metastasis, which is the subtype of poorest prognosis. Chemotherapy is the main treatment, although there is lack of effective adjuvant chemotherapy regimens. The unsatisfactory efficacy of chemotherapy has been a bottleneck in improving the outcome of TNBC. Platinum compounds act directly on DNA to kill tumor cells, and they have a stronger killing effect on tumor cells carrying DNA damage repair (DDR) defects, which is an important entry point to improve the efficacy of TNBC. Biomarkers for predicting the efficacy of platinum drugs in TNBC treatment have always been a hot topic. The DDR pathway contains a large number of related genes, and recent studies have shown that deficiencies in the DDR pathway may be associated with the efficacy of platinum drugs, which is expected to be a biomarker for predicting the efficacy of platinum drugs in breast cancer treatment.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Platinum
/
DNA Damage
/
Pharmaceutical Preparations
/
Antineoplastic Combined Chemotherapy Protocols
/
Platinum Compounds
/
DNA Repair
/
Triple Negative Breast Neoplasms
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Chinese Journal of Oncology
Year:
2022
Type:
Article