Chinese expert consensus on drug interaction management of poly ADP-ribose polymerase inhibitors / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 584-593, 2023.
Article
in Zh
| WPRIM
| ID: wpr-980723
Responsible library:
WPRO
ABSTRACT
Poly ADP-ribose polymerase inhibitors (PARPi), which approved in recent years, are recommended for ovarian cancer, breast cancer, pancreatic cancer, prostate cancer and other cancers by The National Comprehensive Cancer Network (NCCN) and Chinese Society of Clinical Oncology (CSCO) guidelines. Because most of PARPi are metabolized by cytochrome P450 enzyme system, there are extensive interactions with other drugs commonly used in cancer patients. By setting up a consensus working group including pharmaceutical experts, clinical experts and methodology experts, this paper forms a consensus according to the following steps: determine clinical problems, data retrieval and evaluation, Delphi method to form recommendations, finally formation expert opinion on PARPi interaction management. This paper will provide practical reference for clinical medical staff.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Ovarian Neoplasms
/
Adenosine Diphosphate Ribose
/
Consensus
/
Drug Interactions
/
Poly(ADP-ribose) Polymerase Inhibitors
Language:
Zh
Journal:
Chinese Journal of Oncology
Year:
2023
Type:
Article