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Antifungal Activity, Phytochemical Characterization and Thermal Profile of Anadenanthera colubrina (Vell. ) Brenan
Rocha, Eveline Angélica Lira de Souza Sales; Medeiros, Ana Cláudia Dantas de; Castro, Ricardo Dias de; Rosalen, Pedro Luiz; Saraiva, Karina Lidianne Alcântara; Godoy, Gustavo Pina; Silva, Larissa Rodrigues Apolinário da; Aleixo, Cibelle Sousa Silva; Silva, Priscilla Guimarães; Costa, Edja Maria Melo de Brito.
Afiliación
  • Rocha, Eveline Angélica Lira de Souza Sales; s.af
  • Medeiros, Ana Cláudia Dantas de; s.af
  • Castro, Ricardo Dias de; s.af
  • Rosalen, Pedro Luiz; s.af
  • Saraiva, Karina Lidianne Alcântara; s.af
  • Godoy, Gustavo Pina; s.af
  • Silva, Larissa Rodrigues Apolinário da; s.af
  • Aleixo, Cibelle Sousa Silva; s.af
  • Silva, Priscilla Guimarães; s.af
  • Costa, Edja Maria Melo de Brito; s.af
Pesqui. bras. odontopediatria clín. integr ; 17(1): e3389, 13/01/2017. tab, ilus, graf
Artículo en Inglés | LILACS, BBO | ID: biblio-914260
Biblioteca responsable: BR1822.9
ABSTRACT

Objective:

To investigate the antifungal potential of A. colubrina, and its phytochemical characteristics, thermal profile and toxicity. Material and

Methods:

To assess potential antifungal activity, the technique of microdilution was used with the determination of the Minimum Inhibitory Concentration and Minimum Fungicidal Concentration, using standard species of Candida and recent clinical isolates of Candida albicans. Analyses of action of the extract were performed on the wall and cell morphology of C. albicans, of the interactive effect between the plant extract and nystatin on C. albicans through the checkerboard method, and of growth kinetics. The phytochemical screening was determined by spectrophotometry. The thermal profile was traced with the determination of thermogravimetric curves (TG) and differential scanning calorimetry (DSC). The toxicity was evaluated by the method of hemolysis.

Results:

The extract of A. colubrina showed a fungistatic potential against all bacteria tested and it acted by modifying the cellular morphology of C. albicans. There was a synergism between nystatin and the plant extract (FIC=0.375), and 53.18% of total polyphenols were determined. The TG curve showed the occurrence of three steps of thermal decomposition. None of the tested concentrations became the effective cytotoxic concentration.

Conclusion:

Further studies should be conducted to understand the efficacy and the mechanisms of action involved in the antifungal activity of the plant extract of A. colubrina in order to produce a new drug for the treatment of oral candidiasis.
Asunto(s)


Texto completo: Disponible Colección: Bases de datos internacionales Bases de datos: LILACS Métodos Terapéuticos y Terapias MTCI: Terapias Biológicas / Plantas Medicinales Asunto principal: Plantas Medicinales / Candida albicans / Extractos Vegetales / Antifúngicos Tipo de estudio: Estudio de evaluación País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Pesqui. bras. odontopediatria clín. integr Asunto de la revista: Odontología Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Colección: Bases de datos internacionales Bases de datos: LILACS Métodos Terapéuticos y Terapias MTCI: Terapias Biológicas / Plantas Medicinales Asunto principal: Plantas Medicinales / Candida albicans / Extractos Vegetales / Antifúngicos Tipo de estudio: Estudio de evaluación País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Pesqui. bras. odontopediatria clín. integr Asunto de la revista: Odontología Año: 2017 Tipo del documento: Artículo