Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice
Biol. Res
; 51: 21, 2018. graf
Article
en En
| LILACS
| ID: biblio-950905
Biblioteca responsable:
CL1.1
ABSTRACT
OBJECTIVE:
To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N -Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot.RESULTS:
EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice.CONCLUSION:
These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.Palabras clave
Texto completo:
1
Bases de datos:
LILACS
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapéuticos y Terapias MTCI:
Terapias_energeticas
Asunto principal:
Electroacupuntura
/
Ácido Aspártico
/
Ácido Glutámico
/
Hipocampo
/
Aprendizaje
/
Memoria
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Biol. Res
Año:
2018
Tipo del documento:
Article
País de afiliación:
China