Lesion Location in Depression Post Traumatic Brain Injury Using Magnetic Resonance Spectroscopy: Preliminary Results from a Pilot Study

RESUMEN

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ABSTRACT

Objective: To determine the metabolic status of the brain in post traumatic brain injury(TBI) depression using proton magnetic resonance spectroscopy (MRS). DESIGN: Case-control study including 5 TBI depressed subjects and 5 age matched non-TBI non-depressed controls. Methods: Metabolic status was assessed using proton MRS. Ratios of N-acetylaspartate (NAA), choline (Cho) and total creatine (Cr) were calculated in frontal cortex, basal ganglia and thalamus. Results: NAA/Cho or NAA/Cr ratios were significantly reduced in the TBI depressed group compared to controls in frontal cortex, basal ganglia and thalamus. Conclusion: Reduced levels of NAA in frontal regions, basal ganglia and thalamus in TBI depression suggest neuronal damage or dysfunction which may be a associated with the primary brain injury or with depressed mood (AU)