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Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features
Yadav, Sneha; Virendra Tiwari, Virendra; Singh, Manjari; Yadav, Rajnish K; Roy, Subhadeep; Devi, Uma; Gautam, Swetlana; Kumar Rawat, Jitendra Kumar; Ansari, Mohd. Nazam; Saeedan, Abdulaziz Sa; Prakash, Anand; Saraf, Shubhini A; Kaithwas, Gaurav.
Afiliación
  • Yadav, Sneha; Babasaheb Bhimrao Ambedkar University (A Central University). School of Biosciences and Biotechnology. Department of Pharmaceutical Sciences. Lucknow. India
  • Virendra Tiwari, Virendra; Babasaheb Bhimrao Ambedkar University (A Central University). School of Biosciences and Biotechnology. Department of Pharmaceutical Sciences. Lucknow. India
  • Singh, Manjari; Babasaheb Bhimrao Ambedkar University (A Central University). School of Biosciences and Biotechnology. Department of Pharmaceutical Sciences. Lucknow. India
  • Yadav, Rajnish K; Babasaheb Bhimrao Ambedkar University (A Central University). School of Biosciences and Biotechnology. Department of Pharmaceutical Sciences. Lucknow. India
  • Roy, Subhadeep; Babasaheb Bhimrao Ambedkar University (A Central University). School of Biosciences and Biotechnology. Department of Pharmaceutical Sciences. Lucknow. India
  • Devi, Uma; SHIATS- Deemed to be University. Faculty of Health Medical Sciences Indigenous and Alternative Medicine. Department of Pharmaceutical Sciences. Allahabad. India
  • Gautam, Swetlana; Babasaheb Bhimrao Ambedkar University (A Central University). School of Biosciences and Biotechnology. Department of Pharmaceutical Sciences. Lucknow. India
  • Kumar Rawat, Jitendra Kumar; Babasaheb Bhimrao Ambedkar University (A Central University). School of Biosciences and Biotechnology. Department of Pharmaceutical Sciences. Lucknow. India
  • Ansari, Mohd. Nazam; Prince Sattam Bin Abdulaziz University. College of Pharmacy. Department of Pharmacology. AL-Kharj. Arabia Saudi
  • Saeedan, Abdulaziz Sa; Prince Sattam Bin Abdulaziz University. College of Pharmacy. Department of Pharmacology. AL-Kharj. Arabia Saudi
  • Prakash, Anand; Babasaheb Bhimrao Ambedkar University (A Central University). School of Biosciences and Biotechnology. Department of Biotechnology. Lucknow. India
  • Saraf, Shubhini A; Babasaheb Bhimrao Ambedkar University (A Central University). School of Biosciences and Biotechnology. Department of Pharmaceutical Sciences. Lucknow. India
  • Kaithwas, Gaurav; Babasaheb Bhimrao Ambedkar University (A Central University). School of Biosciences and Biotechnology. Department of Pharmaceutical Sciences. Lucknow. India
J. physiol. biochem ; 73(2): 187-198, mayo 2017. graf, tab, ilus
Article en En | IBECS | ID: ibc-168475
Biblioteca responsable: ES1.1
Ubicación: BNCS
ABSTRACT
The present study was undertaken to elucidate the effect of alpha-linolenic acid (ALA, 183, ω-3) and gamma-linolenic acid (GLA, 183, ω-6) on experimental autism features induced by early prenatal exposure to valproic acid (VPA) in albino wistar pups. The pups were scrutinized on the accounts of behavioral, biochemical, and inflammatory markers, and the results suggested that the GLA can impart significant protection in comparison to ALA against VPA-induced autism features. When scrutinized histopathologically, the cerebellum of the GLA-treated animals was evident for more marked protection toward neuronal degeneration and neuronal loss in comparison to ALA. Concomitant administration of ALA and GLA with VPA demonstrated a marked cutdown in the Pgp 9.5 expression with GLA having more pronounced effect. Henceforth, it can be concluded that ALA and GLA can impart favorable protection against the VPA-induced autism-like features with GLA having pronounced effect (AU)
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Bases de datos: IBECS Asunto principal: Trastorno Autístico / Antiinflamatorios no Esteroideos / Ácido gammalinolénico / Ácido alfa-Linolénico / Fármacos Neuroprotectores / Suplementos Dietéticos / Modelos Animales de Enfermedad Idioma: En Revista: J. physiol. biochem Año: 2017 Tipo del documento: Article
Buscar en Google
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Bases de datos: IBECS Asunto principal: Trastorno Autístico / Antiinflamatorios no Esteroideos / Ácido gammalinolénico / Ácido alfa-Linolénico / Fármacos Neuroprotectores / Suplementos Dietéticos / Modelos Animales de Enfermedad Idioma: En Revista: J. physiol. biochem Año: 2017 Tipo del documento: Article