Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases
São Paulo med. j
; 133(2): 164-165, Mar-Apr/2015.
Artículo
en Inglés
| LILACS
| ID: lil-746640
Biblioteca responsable:
BR1.1
ABSTRACT
BACKGROUND:
Our previous systematic review has demonstrated that antioxidant supplements may increase mortality. We have now updated this review.OBJECTIVES:
To assess the beneficial and harmful effects of antioxidant supplements for prevention of mortality in adults.METHODS:
Searchmethods:
We searched The Cochrane Library, Medline, Embase, Lilacs, the Science Citation Index Expanded, and Conference Proceedings Citation Index-Science to February 2011. We scanned bibliographies of relevant publications and asked pharmaceutical companies for additional trials. Selection criteria We included all primary and secondary prevention randomized clinical trials on antioxidant supplements (beta-carotene, vitamin A, vitamin C, vitamin E, and selenium) versus placebo or no intervention. Data collection andanalysis:
Three authors extracted data. Random-effects and fixed-effect model meta-analyses were conducted. Risk of bias was considered in order to minimize the risk of systematic errors. Trial sequential analyses were conducted to minimize the risk of random errors. Random effects model meta-regression analyses were performed to assess sources of intertrial heterogeneity. MAINRESULTS:
Seventy-eight randomized trials with 296,707 participants were included. Fifty-six trials including 244,056 participants had low risk of bias. Twenty-six trials included 215,900 healthy participants. Fifty-two trials included 80,807 participants with various diseases in a stable phase. The mean age was 63 years (range 18 to 103 years). The mean proportion of women was 46%. Of the 78 trials, 46 used the parallel-group design, 30 the factorial design, and 2 the cross-over design. All antioxidants were administered orally, either alone or in combination with vitamins, minerals, or other interventions. The duration of supplementation varied from 28 days to 12 years (mean duration 3 years; median duration 2 years). Overall, the antioxidant supplements had no significant ...
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Bases de datos:
LILACS
Asunto principal:
Prevención Primaria
/
Mortalidad
/
Prevención Secundaria
/
Antioxidantes
Tipo de estudio:
Ensayo clínico controlado
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
São Paulo med. j
Asunto de la revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicina
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Año:
2015
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS