Quinolones and fluoroquinolones are widely used to treat uropathogenic Escherichia coliinfections. Bacterial resistance to these antimicrobials primarily involves mutations in gyrA and parCgenes. To date, no studies have examined the potential relationship between biochemical characteristics and quinolone resistance in uropathogenic E. colistrains. The present work analyzed the quinolonesensitivity and biochemical activities of fifty-eight lactose-negative uropathogenic E. colistrains. A high percentage of the isolates (48.3%) was found to be resistant to at least one of the tested quinolones, and DNA sequencing revealed quinolone resistant determining region gyrA and parCmutations in the multi-resistant isolates. Statistical analyses suggested that the lack of ornithine decarboxylase (ODC) activity is correlated with quinolone resistance. Despite the low number of isolates examined, this is the first study correlating these characteristics in lactose-negative E. coli isolates.
Texto completo:
1
Bases de datos:
LILACS
Métodos Terapéuticos y Terapias MTCI:
Plantas_medicinales
Asunto principal:
Ornitina Descarboxilasa
/
Infecciones Urinarias
/
Ácido Nalidíxico
/
Fluoroquinolonas
/
Farmacorresistencia Bacteriana Múltiple
/
Infecciones por Escherichia coli
/
Escherichia coli Uropatógena
/
Lactosa
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Braz. j. microbiol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Brasil
Texto completo:
1
Bases de datos:
LILACS
Métodos Terapéuticos y Terapias MTCI:
Plantas_medicinales
Asunto principal:
Ornitina Descarboxilasa
/
Infecciones Urinarias
/
Ácido Nalidíxico
/
Fluoroquinolonas
/
Farmacorresistencia Bacteriana Múltiple
/
Infecciones por Escherichia coli
/
Escherichia coli Uropatógena
/
Lactosa
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Braz. j. microbiol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Brasil
Consulta Detalhada
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