Radioiodine-induced oxidative stress in patients with differentiated thyroid carcinoma and effect of supplementation with vitamins C and E and selenium (antioxidants)
Arch. endocrinol. metab. (Online)
; 60(4): 328-332, Aug. 2016. tab, graf
Article
en En
| LILACS
| ID: lil-792949
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT Objective The objective of this study, in addition to confirming that therapy with 131I causes oxidative stress, was to evaluate the effect of supplementation with vitamins C and E and selenium on this phenomenon by measuring plasma 8-epi-PGF2a, a marker of lipid peroxidation. Subjects and methods Forty patients with thyroid cancer submitted to thyroidectomy, who received 3.7 GBq 131I after levothyroxine withdrawal, were selected; 20 patients did not receive (control group) and 20 patients received (intervention group) daily supplementation consisting of 2000 mg vitamin C, 1000 mg vitamin E and 400 µg selenium for 21 days before 131I. Plasma 8-epi-PGF2a was measured immediately before and 2 and 7 days after 131I. Results A significant increase in plasma 8-epi-PGF2a after 131I was observed in the two groups. The concentrations of 8-epi-PGF2α were significantly higher in the control group before and 2 and 7 days after 131I. The percentage of patients with elevated 8-epi-PGF2α was also significantly higher in the control group before and after 131I. Furthermore, the increase (percent) in 8-epi-PGF2α was significantly greater in the control group (average of 112.3% versus 56.3%). Only two patients (10%) reported side effects during supplementation. Conclusions Ablation with 131I causes oxidative stress which can be minimized by the use of antioxidants.
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Texto completo:
1
Bases de datos:
LILACS
Asunto principal:
Neoplasias de la Tiroides
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Carcinoma
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Dinoprost
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Estrés Oxidativo
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Radioisótopos de Yodo
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Antioxidantes
Tipo de estudio:
Observational_studies
Idioma:
En
Revista:
Arch. endocrinol. metab. (Online)
Año:
2016
Tipo del documento:
Article
País de afiliación:
Brasil