Ginkgo biloba extract (EGb 761) protects Na,K-ATPase activity during cerebral ischemia in mice.
Neuroreport
; 10(1): 47-51, 1999 Jan 18.
Article
en En
| MEDLINE
| ID: mdl-10094131
ABSTRACT
Neuroprotective drugs such as Ginkgo biloba extract (EGb 761) could prevent the ischemia-induced impairment of the Na,K-ATPase activity. In this study, Na,K-ATPase activity and expression, contents in fatty acids and malondialdehyde, an index of lipoperoxidation, were compared in the ipsilateral (ischemic) and the contralateral (unlesioned) cortices after 1 h of unilateral focal cortices cerebral ischemia in the mouse. EGb 761 (110 mg/kg) was administered daily to half of the animals for 10 days before ischemia. Ischemia significantly reduced Na,K-ATPase activity by about 40% and increased malondialdehyde content; EGb 761 pretreatment abolished these effects. The free radical scavenger properties of EGb 761 are a potential mechanism by which Na,K-ATPase injury and lipoperoxidation are prevented.
Buscar en Google
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Plantas_medicinales
Asunto principal:
Plantas Medicinales
/
Flavonoides
/
Extractos Vegetales
/
Ataque Isquémico Transitorio
/
ATPasa Intercambiadora de Sodio-Potasio
/
Fármacos Neuroprotectores
/
Ginkgo biloba
Idioma:
En
Revista:
Neuroreport
Año:
1999
Tipo del documento:
Article
País de afiliación:
Francia