The antihyperglycaemic blend effect of traditional chinese medicine byakko-ka-ninjin-to on alloxan and diabetic KK-CA(y) mice.
Phytother Res
; 13(6): 484-8, 1999 Sep.
Article
en En
| MEDLINE
| ID: mdl-10479758
ABSTRACT
The antihyperglycaemic interaction (blend effect) of component crude drugs included in a traditional Chinese prescription, Byakko-ka-ninjin-to (BN; consisted of five crude drugs, ginseng, anemarrhena,-licorice, gypsum and rice) was investigated using genetically obese diabetic KK-CA(y) mice and alloxan-diabetic mice. The water extract of ginseng, anemarrhena, licorice and gypsum when individually tested markedly lowered blood glucose levels in diabetic animals. Antihyperglycaemic effects of ginseng-anemarrhena and ginseng-licorice combinations were decreased compared with the respective individual-effects. Such decreased effects were partially reversed by adding gypsum or by substituting CaCl(2) for gypsum. The combination of D-O-ANa and glycyrrhizin, respectively the main constituents from ginseng and licorice, also demonstrated a decreased effect compared with the respective individual effects. The CaCl(2) at 0.5 mg/kg (i.p.) was sufficient to partially reverse these effects. These results indicate that antihyperglycaemic effects of BN depend on four crude drugs and Ca(2+) in the blend.
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Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
/
Plantas_medicinales
Asunto principal:
Plantas Medicinales
/
Saponinas
/
Medicamentos Herbarios Chinos
/
Diabetes Mellitus Experimental
/
Diabetes Mellitus Tipo 2
/
Hipoglucemiantes
/
Medicina Tradicional China
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Phytother Res
Año:
1999
Tipo del documento:
Article
País de afiliación:
Japón