Effects of inhalation of corticosteroids immediately after experimental chlorine gas lung injury.
J Trauma
; 48(1): 101-7, 2000 Jan.
Article
en En
| MEDLINE
| ID: mdl-10647573
ABSTRACT
BACKGROUND:
To assess the effects of treatment with nebulized corticosteroids immediately after chlorine gas injury.METHODS:
Eighteen anesthetized and mechanically ventilated pigs were exposed to chlorine gas (140 ppm for 10 minutes) and observed for 6 hours. Nine pigs were treated with nebulized beclomethasone-dipropionate 20 microg/kg (BDP group), and nine pigs were given no treatment (control group).RESULTS:
All animals developed severe pulmonary dysfunction. The initial decrease in PaO2 was similar in both groups, but BDP-treated animals improved whereas control animals deteriorated (p < 0.005; analysis of variance). Pulmonary vascular resistance increased in both groups but less in the BDP group (p < 0.01). Lung-thorax compliance was better preserved in the BDP group (p < 0.01), and oxygen delivery was significantly better in the BDP group (p < 0.01). One animal died in the BDP group, as did three animals in the control group.CONCLUSION:
Immediate treatment with nebulized BDP improved pulmonary and cardiovascular function after experimental chlorine gas injury.
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Bases de datos:
MEDLINE
Asunto principal:
Edema Pulmonar
/
Beclometasona
/
Cloro
/
Gases
/
Antiinflamatorios
Idioma:
En
Revista:
J Trauma
Año:
2000
Tipo del documento:
Article
País de afiliación:
Suecia