GABA transporters (GAT-1) in Alzheimer's disease.
J Neural Transm (Vienna)
; 106(11-12): 1141-9, 1999.
Article
en En
| MEDLINE
| ID: mdl-10651110
ABSTRACT
The presynaptically located gamma-aminobutyric acid (GABA) transporter (GAT-1) was studied in a group of patients with Alzheimer's disease (AD) and in a control group using the GAT-1 selective radioligand [3H]tiagabine. Post mortem brain tissue from frontal cortex, temporal cortex, and caudate nucleus from 18 AD patients and 23 age-matched controls were studied. The binding was saturable (Kd 26 nM) and region specific. There were no significant differences between the groups with respect to the binding capacity (Bmax) and binding affinity (Kd). The unaltered [3H]tiagabine binding to GAT-1 protein indicates that intrinsic GABA neurons are spared in Alzheimer's disease.
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Bases de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Membrana
/
Química Encefálica
/
Proteínas Portadoras
/
Transportadores de Anión Orgánico
/
Enfermedad de Alzheimer
/
Proteínas de la Membrana
Idioma:
En
Revista:
J Neural Transm (Vienna)
Año:
1999
Tipo del documento:
Article
País de afiliación:
Suecia