Isolation and characterization of a human cDNA encoding a protein homologous to the 7.2-kDa protein (subunit X) of bovine ubiquinol-cytochrome C reductase.
J Hum Genet
; 45(1): 43-6, 2000.
Article
en En
| MEDLINE
| ID: mdl-10697962
ABSTRACT
Through large-scale sequencing of clones randomly selected from a library of human cDNAs, we have isolated a novel human gene termed hUQCR10. Its open reading frame encodes 63 amino acids that share 88.5% identity with the sequence of bovine ubiquinol-cytochrome C reductase 7.2-kDa protein (subunit X). A single 0.6-kb transcript was expressed in all human tissues examined, but was particularly abundant in heart and skeletal muscle, tissues that consume a large amount of oxygen. The gene product therefore may play a significant role in the cellular respiratory system. In support of this hypothesis, our immunohistochemical analysis revealed that the hUQCR10 protein is located in mitochondria. A homology search using computer programs determined the chromosomal localization of the gene at 22q12.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Complejo III de Transporte de Electrones
Idioma:
En
Revista:
J Hum Genet
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón