Effects of luteolin on arylamine N-acetyltransferase activity in rat blood and liver.
Phytomedicine
; 7(1): 49-54, 2000 Mar.
Article
en En
| MEDLINE
| ID: mdl-10782490
ABSTRACT
In this study we investigated inhibition of Arylamine N-acetyltransferase (NAT) activity in rat blood and liver tissue cytosols by luteolin. Using high-performance liquid chromatography, NAT activity for acetylation of 2-aminofluorene and remaining unacetylated 2-aminofluorene were examined. The NAT activity in rat blood and liver tissue was inhibited by luteolin in a dose-dependent manner higher concentrations of luteolin in the reaction resulted in greater inhibition of NAT activities in both examined tissues. The data also indicated that luteolin decreased apparent Km and Vmax of NAT enzymes from rat blood and liver tissue cytosols. This report is the first demonstration that luteolin can affect rat blood and liver tissue NAT activity.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Plantas Medicinales
/
Arilamina N-Acetiltransferasa
/
Flavonoides
/
Inhibidores Enzimáticos
/
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Idioma:
En
Revista:
Phytomedicine
Año:
2000
Tipo del documento:
Article
País de afiliación:
Taiwán