[Hyperhomocysteinemia and pregnancy: a dangerous association]. / Hyperhomocystéinémie et grossesse : une association dangereuse.
J Gynecol Obstet Biol Reprod (Paris)
; 29(4): 363-72, 2000 Jun.
Article
en Fr
| MEDLINE
| ID: mdl-10844324
ABSTRACT
Homocysteine results from the demethylation of the essential amino acid methionine. Its metabolism depends primarily on three enzymes and several vitamin cofactors (vit. B6, B9 and B12). Genetic abnormality in these enzymes or deficiency of these vitamins lead to Hyperhomocysteinemia. Hyperhomocysteinemia belongs among the congenital thrombophilies and is a long-known vascular disease risk factor. The discovery that hyperhomocysteinemia may also be responsible for several pregnancy complications has only recently been made. Studies in this area are still scarce and report on limited numbers of patients. It nevertheless appears clear that HHCh is associated with the syndromes of repeated miscarriage, pre-eclampsia, placenta abruptio, thromboembolic events, neural tube defects, and perhaps with fetal death-in-utero and intra-uterine growth retardation. Supplementation with vitamin B9 can reduce plasma HC levels, and is thus recommended in patients with HHCh. The prevention of thromboembolic events during pregnancy by anticoagulant treatment is also desirable in these patients.
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Bases de datos:
MEDLINE
Asunto principal:
Complicaciones del Embarazo
/
Hiperhomocisteinemia
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Idioma:
Fr
Revista:
J Gynecol Obstet Biol Reprod (Paris)
Año:
2000
Tipo del documento:
Article