Total synthesis of a new cytotoxic acetogenin, jimenezin, and the revised structure.
Org Lett
; 1(12): 2025-8, 1999 Dec 16.
Article
en En
| MEDLINE
| ID: mdl-10905863
ABSTRACT
The first total synthesis of jimenezin was achieved by using carbohydrates as chiral building blocks, thus revising the proposed structure 1 to 2. The key steps in this synthesis include an efficient construction of the THP-THF fragments 3 and 16 through a stereoselective condensation between the pyranyl aldehyde 5 and the acetylene derivative 6, and a palladium-catalyzed coupling reaction of 3 or 16 with a terminal butenolide 4.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Piranos
/
Furanos
/
Antineoplásicos Fitogénicos
Idioma:
En
Revista:
Org Lett
Año:
1999
Tipo del documento:
Article
País de afiliación:
Japón