[Major aphthous stomatitis (Sutton's disease): etiopathogenesis, histological and clinical aspects]. / Stomatite aftosa major (malattia di Sutton). Etiopatogenesi, quadri istologici ed aspetti clinici.
Minerva Stomatol
; 49(1-2): 41-50, 2000.
Article
en It
| MEDLINE
| ID: mdl-10932907
ABSTRACT
Major aphthous stomatitis (Sutton's disease) is a clinical variant of recurrent aphthous stomatitis differentiated by its high level of morbidity. It is generally found in areas of non-keratinized mucosa and is characterised by the presence of necrotic giant ulcers accompanied by intense pain. While this pathology has been the subject of molecular studies, its etiopathogenesis is still unknown. The most widely accredited hypothesis is that it represents an immune mechanism, namely the immunological response of mucosa with antigenic anomalies, modulated by altered local reactivity and influenced by triggering factors. After an extensive review of the various etiopathogenetic hypotheses, clinical and pathological aspects, the authors outline a number of therapeutic protocols including the use of topical and systemic cortisone, immunomodulators and alternative therapies like laser and ultrasound, or medications to protect the ulcers. They stress that the lack of etiopathogenetic uniformity precludes any specific treatment.
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Bases de datos:
MEDLINE
Asunto principal:
Estomatitis Aftosa
Tipo de estudio:
Guideline
Idioma:
It
Revista:
Minerva Stomatol
Año:
2000
Tipo del documento:
Article