Changes in phosphoinositide signalling activity and levels of the alpha subunit of G(q/11) protein in rat brain induced by E-5842, a sigma(1) receptor ligand and potential atypical antipsychotic.
Neurosci Lett
; 290(3): 189-92, 2000 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-10963895
ABSTRACT
Changes in the phosphoinositide (PPI) signal transduction system induced by E-5842, a new sigma(1) (sigma(1)) receptor ligand and potential atypical antipsychotic, were studied in the rat frontal cortex, hippocampus and striatum. Acute treatment with E-5842 increased phospholipase C (PLC) activity in the striatum and the hippocampus. Chronic treatment with E-5842 induced an increase in the activity of PLC in the frontal cortex and the striatum. Similar up-regulation of the activity of the enzyme was also observed in rat frontal cortex membranes in presence of GTPgammaS. After chronic treatment with E-5842, it was also observed a significant increase of the immunoreactivity levels of G(q/11)alpha in the frontal cortex. Our results suggest that part of the antipsychotic effects of E-5842 could be related to the regulation of the PPI signal transduction pathway, especially after a prolonged treatment.
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Bases de datos:
MEDLINE
Asunto principal:
Fosfatidilinositoles
/
Fosfolipasas de Tipo C
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Piridinas
/
Antipsicóticos
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Triazoles
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Encéfalo
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Transducción de Señal
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Receptores sigma
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Proteínas de Unión al GTP
Idioma:
En
Revista:
Neurosci Lett
Año:
2000
Tipo del documento:
Article
País de afiliación:
España