Serum total homocysteine concentration is related to self-reported heart attack or stroke history among men and women in the NHANES III.
J Nutr
; 130(12): 3073-6, 2000 Dec.
Article
en En
| MEDLINE
| ID: mdl-11110872
ABSTRACT
High circulating total homocysteine (tHcy) concentration, which is influenced by folate and vitamin B-12 status, is a suspected cause of cardiovascular events. This relation has been investigated in both case-control and prospective studies but has not been evaluated for different sex x age subgroups of the general U.S. population. We used data on adult (i.e., aged > or =40 y) male (n = 1097) and female (n = 1107) participants in the third National Health and Nutrition Examination Survey, excluding diabetics and those supplemented with estrogen, vitamins or minerals, to evaluate the association between serum tHcy concentration and self-report of heart attack or stroke. After adjustment for age, race-ethnicity, smoking, blood pressure, blood pressure medication, body mass index and serum concentrations of creatinine and cholesterol, past events were reported 2.4 (95% confidence interval 1.0-5.5) times as often by men with tHcy concentration of >12 micromol/L as by men with lower values. The odds ratio for women was 2.6 (95% confidence interval 1.1-6.6) after adjustment for the same factors plus menopausal status. A stronger relation in men aged < or =60 y compared with older men may help reconcile conflicting results of earlier studies.
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Bases de datos:
MEDLINE
Asunto principal:
Autorrevelación
/
Hiperhomocisteinemia
/
Accidente Cerebrovascular
/
Paro Cardíaco
/
Homocisteína
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Nutr
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos