Recruitment of CD1a+ Langerhans cells to the nasal mucosa in seasonal allergic rhinitis and effects of topical corticosteroid therapy.
Allergy
; 56(2): 126-31, 2001 Feb.
Article
en En
| MEDLINE
| ID: mdl-11167372
ABSTRACT
BACKGROUND:
Local antigen presentation may be necessary for both primary and recall T-cell responses to grass pollen in hay fever patients. We examined the effect of seasonal allergen exposure on nasal mucosal antigen-presenting cell (APC) populations and the effects of topical corticosteroid therapy.METHODS:
Nasal biopsies were collected from 46 grass pollen-sensitive seasonal rhinitis patients before the grass-pollen season. A second biopsy was collected during the pollen season, when patients had received 6 weeks' treatment with either fluticasone propionate (200 microg, twice daily) or placebo. Cell populations in biopsy sections were quantified by immunocytochemistry.RESULTS:
Significant increases in submucosal and epithelial CD1a+ Langerhans cells, but not CD68 + macrophages or CD20 + B cells, were observed during the pollen season. Seasonal increases in CD1a+ Langerhans cells were inhibited by corticosteroid therapy.CONCLUSIONS:
Recruitment of CD1a+ Langerhans cells to the nasal mucosa during natural seasonal allergen exposure may contribute to local T cell responses. Topical corticosteroids may act, at least in part, by inhibiting effective allergen presentation to T cells through inhibition of recruitment of Langerhans cells to the nasal mucosa.
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Bases de datos:
MEDLINE
Asunto principal:
Rinitis Alérgica Estacional
/
Células de Langerhans
/
Antígenos CD1
/
Androstadienos
/
Mucosa Nasal
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
Allergy
Año:
2001
Tipo del documento:
Article
País de afiliación:
Reino Unido