Growth inhibitory effect of green tea extract in Ehrlich ascites tumor cells involves cytochrome c release and caspase activation.
Cancer Lett
; 166(1): 9-15, 2001 May 10.
Article
en En
| MEDLINE
| ID: mdl-11295281
ABSTRACT
We reported previously that the mechanism by which Green tea extract (GTE) elicited growth-inhibitory effects in Ehrlich ascites tumor cells involved a decrease in ornithine decarboxylase (ODC) activity and in cell viability. Decrease in ODC activity has been associated with apoptotic cell death and we therefore studied changes in cytochrome c release and caspase activation, which characterize apoptosis. GTE caused a dose- and time-dependent increase in caspase-3-like protease activation, preceded by a release of cytochrome c from the mitochondria. Inhibiting the activation of caspase-3 with acetyl-Asp-Glu-Val-Asp-alpha-aldehyde (caspase inhibitor) caused a reversal in the effect on cell viability.
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Bases de datos:
MEDLINE
Asunto principal:
Té
/
Carcinoma de Ehrlich
/
Apoptosis
/
Caspasas
/
Grupo Citocromo c
Idioma:
En
Revista:
Cancer Lett
Año:
2001
Tipo del documento:
Article
País de afiliación:
Japón