Toxicity testing of Senna occidentalis seed in rabbits.
Vet Res Commun
; 24(8): 573-82, 2000 Dec.
Article
en En
| MEDLINE
| ID: mdl-11305748
ABSTRACT
The effect was investigated of administering ground Senna occidentalis seeds to rabbits in different concentrations (1%, 2%, 3% and 4%) in the ration. The experiment lasted 30 days and the toxic effects of the plant were evaluated on the basis of weight gain, histopathological, biochemical and morphometric parameters, as well as histochemistry and electron microscopy. Animals that received the ration containing 4% ground S. occidentalis seeds gained less weight (p < 0.05) and died in the third week. Histopathology revealed that the heart and liver were the main organs affected, with myocardial necrosis and centrolobular degeneration. There was a reduction in cytochrome oxidase activity in the glycogenolytic fibres, together with muscle atrophy, confirmed by the morphometric studies. Electron microscopy of the liver cells revealed dilated mitochondria, with destruction of the internal cristae.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Plantas Medicinales
/
Semillas
/
Cassia
/
Hígado
/
Miocardio
Idioma:
En
Revista:
Vet Res Commun
Año:
2000
Tipo del documento:
Article
País de afiliación:
Brasil